Deficits in cerebellum-dependent learning and cerebellar morphology in male and female BTBR autism model mice.

ABSTRACT: Recently, there has been increased interest in the role of the cerebellum in autism spectrum disorders (ASD). To better understand the pathophysiological role of the cerebellum in ASD, it is necessary to have a variety of mouse models that have face validity for cerebellar disruption in humans. Here, we add to the literature on the cerebellum transgenic and induced mouse models of autism with the characterization of the cerebellum in the BTBR T+Itpr3^tf/J (BTBR) inbred mouse strain, which has behavioral phenotypes that are suggestive of ASD in patients. When we examined both male and female BTBR mice in comparison to C57BL/6J (C57) controls, we noted that both sexes of BTBR mice showed motor coordination deficits characteristic of cerebellar dysfunction, but only the male mice sh

SUBMITTER: Kiffmeyer EA 

PROVIDER: S-EPMC10292658 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature