Identification of potential biomarkers in active Lyme borreliosis.

ABSTRACT:

Objectives

Lyme serology does not readily discriminate an active Lyme borreliosis (LB) from a previous Borrelia infection or exposure. Here, we aimed to investigate a large number of immunological protein biomarkers to search for an immunological pattern typical for active LB, in contrast to patterns found in healthy blood donors, a proportion of whom were previously exposed to Borrelia.

Methods

Serum samples from well-characterised adult patients with ongoing LB and healthy blood donors were included and investigated using a proximity extension assay (provided by Olink®) by which 92 different immune response-related human protein biomarkers were analysed simultaneously.

Results

In total, 52 LB patients and 75 healthy blood donors were included. The blood donors repre

SUBMITTER: Tjernberg I 

PROVIDER: S-EPMC10292690 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature