When words first fail: Predicting the emergence of primary progressive aphasia variants from unclassifiable anomic performance in early disease.

ABSTRACT:

Background

The majority of patients with primary progressive aphasia (PPA) can be distinguished into one of three variants: semantic, non-fluent/agrammatic, or logopenic. However, many do not meet criteria for any one variant.

Aim

To identify aspects of cognitive-linguistic performance that yield an early unclassifiable PPA designation that predicted the later emergence of a given variant.

Methods & procedures

Of 256 individuals with PPA evaluated, 19 initially were unclassifiable and later met criteria for a variant. Receiver operating characteristic curves were used to evaluate the binary ability of a given task to predict eventual classification as a given variant. Tasks with a high area under the curve were examined using regression analyses to determine their abi

SUBMITTER: Stockbridge MD 

PROVIDER: S-EPMC10292722 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature