Genetics of Diabetic Retinopathy.

ABSTRACT:

Purpose of review

The goal of this paper is to review the latest findings in understanding the genetics of diabetic retinopathy. We highlight recent literature using a variety of molecular genetic techniques to identify variants which contribute to genetic susceptibility for diabetic retinopathy.

Recent findings

New genome-wide association study (GWAS) and whole-exome sequencing approaches have been utilized to identify both common and rare variants associated with diabetic retinopathy. While variants have been identified in isolated studies, no variants have been replicated across multiple studies. The identification of genetic factors associated with diabetic retinopathy remains elusive. This is due to the multifactorial nature of the disease, small sample sizes for GWAS,

SUBMITTER: Han J 

PROVIDER: S-EPMC10292832 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature