Network pharmacology-based research on the effect of angelicin on osteosarcoma and the underlying mechanism.

ABSTRACT: To explore the antitumor effects of angelicin on osteosarcoma and the underlying mechanism. We aimed to elucidate the mechanism by network pharmacology, molecular docking, and in vitro experiments. We analyzed a PPI network of potential angelicin targets in the treatment of osteosarcoma and identified hub targets. We systematically performed GO and KEGG enrichment analyses of the potential targets of angelicin, and we predicted it function in osteosarcoma treatment and the underlying molecular mechanism. Through molecular docking, the interactions between hub targets and angelicin were simulated, and then, the hub targets of angelicin were identified. Based on these results, we validated the effects of angelicin on osteosarcoma cells by conducting in vitro experiments. The PP

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10292874 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature