Identification of a novel MSI-related ceRNA network for predicting the prognosis and immunotherapy response of gastric cancer.

ABSTRACT:

Background

Mounting evidence has underscored the pivotal role of the competitive endogenous RNA (ceRNA) regulatory networks among various cancers. However, the behavior characteristics and complexity of the ceRNA network in Gastric cancer (GC) remains unclear. In this study, we aimed to clarify a Microsatellite instability (MSI)-related ceRNA regulatory network and identify potential prognostic markers associated with GC.

Methods and results

We extracted transcriptome data of GC patients from The Cancer Genome Atlas (TCGA) and identified differentially expressed lncRNAs, miRNAs and mRNAs based on MSI status. A hub ceRNA network including 1 lncRNAs (MIR99AHG), 2 miRNAs and 26 mRNAs specific to MSI was established in GC. We further constructed a prognostic model with seven tar

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10292885 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature