A spliceosome-associated gene signature aids in predicting prognosis and tumor microenvironment of hepatocellular carcinoma.

ABSTRACT: Splicing alterations have been shown to be key tumorigenesis drivers. In this study, we identified a novel spliceosome-related genes (SRGs) signature to predict the overall survival (OS) of patients with hepatocellular carcinoma (HCC). A total of 25 SRGs were identified from the GSE14520 dataset (training set). Univariate and least absolute shrinkage and selection operator (LASSO) regression analyses were utilized to construct the signature using genes with predictive significance. We then constructed a risk model using six SRGs (BUB3, IGF2BP3, RBM3, ILF3, ZC3H13, and CCT3). The reliability and predictive power of the gene signature were validated in two validation sets (TCGA and GSE76427 dataset). Patients in training and validation sets were divided into high and low-risk groups based on

SUBMITTER: Wang H 

PROVIDER: S-EPMC10292887 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature