Construction and validation of an oxidative-stress-related risk model for predicting the prognosis of osteosarcoma.

ABSTRACT:

Background

Osteosarcoma is the most common bone malignancy in teenagers, and warrants effective measures for diagnosis and prognosis. Oxidative stress (OS) is the key driver of several cancers and other diseases.

Methods

The TARGET-osteosarcoma database was employed as the training cohort and GSE21257 and GSE39055 was applied for external validation. The patients were classified into the high- and low-risk groups based on the median risk score of each sample. ESTIMATE and CIBERSORT were applied for the evaluation of tumor microenvironment immune infiltration. GSE162454 of single-cell sequencing was employed for analyzing OS-related genes.

Results

Based on the gene expression and clinical data of 86 osteosarcoma patients in the TARGET database, we identified eight OS-r

SUBMITTER: Wang H 

PROVIDER: S-EPMC10292890 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature