KIF20A as a potential biomarker of renal and bladder cancers based on bioinformatics and experimental verification.

ABSTRACT:

Background

Bladder cancer (BC) is a malignant tumor that occurs in the bladder wall and often appears in elderly individuals. Renal cancer (RC) arises from the renal tubular epithelium, but its molecular mechanism remains unclear.

Methods

We downloaded RC datasets (GSE14762 and GSE53757) and a BC dataset (GSE121711) to screen differentially expressed genes (DEGs). We also performed weighted gene coexpression network analysis (WGCNA). We created a protein-protein interaction (PPI) network and performed functional enrichment analysis, such as gene set enrichment analysis (GSEA). Heatmaps were made for gene expression. Survival analysis and immunoinfiltration analysis were performed. Comparative toxicogenomics database (CTD) analysis was performed to find the relationship betwe

SUBMITTER: Wang H 

PROVIDER: S-EPMC10292905 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature