Impact of asthma on the brain: evidence from diffusion MRI, CSF biomarkers and cognitive decline.

ABSTRACT: Chronic systemic inflammation increases the risk of neurodegeneration, but the mechanisms remain unclear. Part of the challenge in reaching a nuanced understanding is the presence of multiple risk factors that interact to potentiate adverse consequences. To address modifiable risk factors and mitigate downstream effects, it is necessary, although difficult, to tease apart the contribution of an individual risk factor by accounting for concurrent factors such as advanced age, cardiovascular risk, and genetic predisposition. Using a case-control design, we investigated the influence of asthma, a highly prevalent chronic inflammatory disease of the airways, on brain health in participants recruited to the Wisconsin Alzheimer's Disease Research Center (31 asthma patients, 186 non-asthma contro

SUBMITTER: Nair AK 

PROVIDER: S-EPMC10292933 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature