Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation.

ABSTRACT: The immune-specialized environment of the healthy brain is tightly regulated to prevent excessive neuroinflammation. However, after cancer development, a tissue-specific conflict between brain-preserving immune suppression and tumor-directed immune activation may ensue. To interrogate potential roles of T cells in this process, we profiled these cells from individuals with primary or metastatic brain cancers via integrated analyses on the single-cell and bulk population levels. Our analysis revealed similarities and differences in T cell biology between individuals, with the most pronounced differences observed in a subgroup of individuals with brain metastasis, characterized by accumulation of CXCL13-expressing CD39⁺ potentially tumor-reactive T (pTRT) cells. In this subgroup,

SUBMITTER: Wischnewski V 

PROVIDER: S-EPMC10293012 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature