Cancer Microenvironment Defines Tumor-Infiltrating Lymphocyte Density and Tertiary Lymphoid Structure Formation in Laryngeal Cancer.

ABSTRACT:

Background

The presence and activity of tumor-infiltrating lymphocytes (TILs) is a key parameter related to the antitumor immune response. A large number of studies reveal TIL density as a prognostic marker and predictor of response to radiotherapy, chemotherapy, and immunotherapy.

Methods

We examined the TIL and tertiary lymphoid structure TLS density in the invading front and inner tumor stroma, in a 33 squamous cell laryngeal carcinomas (LSCC) treated with laryngectomy. TIL and TLS densities were in parallel examined with markers of anaerobic metabolism, vascular density (VD), vascular survival ability (VSA), and histopathological parameters.

Results

TIL and TLS densities significantly decreased in inner tumor areas (p < 0.0001). TIL density in the invading tumor f

SUBMITTER: Gkegka AG 

PROVIDER: S-EPMC10293152 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature