N-Acetyl-L-Cysteine Reduces Cervical Carcinogenesis by Promoting Apoptosis.

ABSTRACT:

Background and objective

Cervical cancer is the fourth leading cause of cancer death in women, and is one of the most common malignant tumors of the reproductive system. However, more effective treatment for cervical cancer is needed. In this study, we aim to investigate whether N-acetyl-L-cysteine (NAC) could inhibit the proliferation of human papillomavirus (HPV)-positive cells, and reduce cervical carcinogenesis.

Methods

The cervical cancer cell lines SiHa, HeLa, HPV-negative cell line C33A, and the immortalized human cervical keratinocyte cells S12 were used. The protein expression was determined using Western blot assay. mRNA expression was determined using quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cell proliferation was determined by Cell

SUBMITTER: Guo W 

PROVIDER: S-EPMC10293158 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature