Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia.

ABSTRACT: The adult heart displays poor reparative capacities after injury. Cell transplantation and tissue engineering approaches have emerged as possible therapeutic options. Several stem cell populations have been largely used to treat the infarcted myocardium. Nevertheless, transplanted cells displayed limited ability to establish functional connections with the host cardiomyocytes. In this study, we provide a new experimental tool, named 3D eX vivo muscle engineered tissue (X-MET), to define the contribution of mechanical stimuli in triggering functional remodeling and to rescue cardiac ischemia. We revealed that mechanical stimuli trigger a functional remodeling of the 3D skeletal muscle system toward a cardiac muscle-like structure. This was supported by molecular and functional analyses, dem

SUBMITTER: Cosentino M 

PROVIDER: S-EPMC10293177 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature