Striatal cholinergic interneuron membrane voltage tracks locomotor rhythms in mice.

ABSTRACT: Rhythmic neural network activity has been broadly linked to behavior. However, it is unclear how membrane potentials of individual neurons track behavioral rhythms, even though many neurons exhibit pace-making properties in isolated brain circuits. To examine whether single-cell voltage rhythmicity is coupled to behavioral rhythms, we focused on delta-frequencies (1-4 Hz) that are known to occur at both the neural network and behavioral levels. We performed membrane voltage imaging of individual striatal neurons simultaneously with network-level local field potential recordings in mice during voluntary movement. We report sustained delta oscillations in the membrane potentials of many striatal neurons, particularly cholinergic interneurons, which organize spikes and network oscillations at

SUBMITTER: Shroff SN 

PROVIDER: S-EPMC10293266 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature