Cortical and Subcortical Changes in MEG Activity Reflect Parkinson's Progression over a Period of 7 Years.

ABSTRACT: In this study of early functional changes in Parkinson's disease (PD), we aimed to provide a comprehensive assessment of the development of changes in both cortical and subcortical neurophysiological brain activity, including their association with clinical measures of disease severity. Repeated resting-state MEG recordings and clinical assessments were obtained in the context of a unique longitudinal cohort study over a seven-year period using a multiple longitudinal design. We used linear mixed-models to analyze the relationship between neurophysiological (spectral power and functional connectivity) and clinical data. At baseline, early-stage (drug-naïve) PD patients demonstrated spectral slowing compared to healthy controls in both subcortical and cortical brain regions, most outspoken

SUBMITTER: Boon LI 

PROVIDER: S-EPMC10293384 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature