Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects.

ABSTRACT: The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens are being used for research, including postmortem brains, cerebrospinal fluid, induced pluripotent stem (iPS) cells, and induced neuronal (iN) cells. However, these samples are far from providing a useful predictive, diagnostic, or prognostic biomarker. The olfactory epithelium is a region close to the brain that has received increased interest as a research tool for the study of brain mechanisms in complex neuropsychiatric and neurological diseases. The olfactory sensory neurons are replaced by neurogenesis throughout adult life from stem cells on the basement membrane. These stem cells are multipotent and can

SUBMITTER: Unzueta-Larrinaga P 

PROVIDER: S-EPMC10293402 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature