Diagnostic tests for medullary thyroid carcinoma: an umbrella review.

ABSTRACT:

Purpose

To summarize the more robust evidence about the performance of tools useful for diagnosis of medullary thyroid carcinoma (MTC) such as calcitonin (Ctn) and other circulating markers, ultrasound (US), fine-needle aspiration (FNA), and other imaging procedures.

Methods

This systematic review of systematic reviews was carried out according to a predefined protocol. A search string was created. An electronical comprehensive search of literature was performed on December 2022. Quality assessment of eligible systematic reviews was performed and main findings were described.

Results

Twenty-three systematic reviews were included and several findings were achieved. Ctn is the most reliable diagnostic marker of MTC with no evidence of improvement with stimulation test.

SUBMITTER: Trimboli P 

PROVIDER: S-EPMC10293444 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature