PRAME Staining in Sinonasal Mucosal Melanoma: A Single-Center Experience.

ABSTRACT:

Background

Sinonasal mucosal melanoma (MM) is a rare, aggressive melanoma subtype. Complete surgical excision, with or without adjuvant radiotherapy, remains the cornerstone of treatment and yields adequate locoregional control. Metastatic MM is managed similarly to metastatic cutaneous melanoma but with poorer survival. PReferentially expressed Antigen in MElanoma (PRAME) has been identified as a potential diagnostic marker and therapeutic target in the treatment of cutaneous melanoma.

Methods

Retrospective analysis of the clinical characteristics and immunohistochemical features of all sinonasal MM patients referred to the department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, between 2011 and 2021 was performed. Single nucleotide polymorphism (SNP) arra

SUBMITTER: Scheurleer WFJ 

PROVIDER: S-EPMC10293483 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature