Prognostic Genomic Markers of Pathological Stage in Oral Squamous Cell Carcinoma.

ABSTRACT:

Background

To identify the prognostic markers of oral squamous cell carcinoma (OSCC), the genetic heterogeneity of the pathological stages was investigated.

Methods

The data of 295 patients with primary OSCC obtained from the Cancer Genome Atlas were studied. The genetic prognostic landscape of the pathological stages was systematically analyzed by Cox regressions, Fisher's exact tests, and Gene Ontology (GO) enrichment.

Results

Stage 4 patients had a poor prognosis in univariate and multivariate Cox models. Transforming growth factor-beta (TGF-β) pathway alterations were found more frequently in stage 4, whereas alterations in cell cycle pathways were significant in stages 1, 2, and 3. The differentially mutated genes were divided into three groups: risk genes of hig

SUBMITTER: Kuk SK 

PROVIDER: S-EPMC10293537 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature