Multiscale model of the different modes of cancer cell invasion.

ABSTRACT:

Motivation

Mathematical models of biological processes altered in cancer are built using the knowledge of complex networks of signaling pathways, detailing the molecular regulations inside different cell types, such as tumor cells, immune and other stromal cells. If these models mainly focus on intracellular information, they often omit a description of the spatial organization among cells and their interactions, and with the tumoral microenvironment.

Results

We present here a model of tumor cell invasion simulated with PhysiBoSS, a multiscale framework, which combines agent-based modeling and continuous time Markov processes applied on Boolean network models. With this model, we aim to study the different modes of cell migration and to predict means to block it by consideri

SUBMITTER: Ruscone M 

PROVIDER: S-EPMC10293590 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature