Clinical trial of a probiotic and herbal supplement for lung health.

ABSTRACT:

Introduction

Dysbiosis of the gut microbiome may augment lung disease via the gut-lung axis. Proteobacteria may contribute to tissue proteolysis followed by neutrophil recruitment, lung tissue injury, and perpetuation of chronic inflammation. To study the effects of probiotics across the gut-lung axis, we sought to determine if a Lactobacillus probiotic and herbal blend was safe and well-tolerated in healthy volunteers and asthmatic patients.

Methods

We conducted a 1-month randomized, open-label clinical trial in Cork, Ireland with healthy and asthmatic patients who took the blend twice a day. The primary endpoint was safety with exploratory endpoints including quality of life, lung function, gut microbiome ecology, and inflammatory biomarkers.

Results

All subj

SUBMITTER: Wenger NM 

PROVIDER: S-EPMC10293651 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature