Ranking the risk factors for Alzheimer's disease; findings from the UK Biobank study.

ABSTRACT:

Background

The cause of the most common form of dementia, sporadic Alzheimer's disease (AD), remains unknown. This may reflect insufficiently powered studies to date for this multi-factorial disorder. The UK Biobank dataset presents a unique opportunity to rank known risk factors and determine novel variables.

Methods

A custom machine learning approach for high dimensionality data was applied to explore prospectively associations between AD in a sub-cohort of 156,209 UK Biobank participants aged 60-70 including more than 2,090 who were subsequently diagnosed with AD.

Results

After the possession of the APOE4 allele, the next highest ranked risk factors were other genetic variants within the TOMM40-APOE-APOC1 locus. When stratified by their apolipoprotein epsilon 4 (AP

SUBMITTER: Allwright M 

PROVIDER: S-EPMC10293768 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature