IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system.

ABSTRACT: The objective of this study is to examine IL-11-induced mechanisms of inflammatory cell migration to the central nervous system (CNS). We report that IL-11 is produced at highest frequency by myeloid cells among the peripheral blood mononuclear cell (PBMC) subsets. Patients with relapsing-remitting multiple sclerosis (RRMS) have an increased frequency of IL-11⁺ monocytes, IL-11⁺ and IL-11R⁺ CD4⁺ lymphocytes, and IL-11R⁺ neutrophils in comparison to matched healthy controls. IL-11⁺ and granulocyte-macrophage colony-stimulating factor (GM-CSF)⁺ monocytes, CD4⁺ lymphocytes, and neutrophils accumulate in the cerebrospinal fluid (CSF). The effect of IL-11 in-vitro stimulation, examined using single-cell RNA

SUBMITTER: Seyedsadr M 

PROVIDER: S-EPMC10293805 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature