Gating of homeostatic regulation of intrinsic excitability produces cryptic long-term storage of prior perturbations.

ABSTRACT: Neurons and neuronal circuits must maintain their function throughout the life of the organism despite changing environments. Previous theoretical and experimental work suggests that neurons monitor their activity using intracellular calcium concentrations to regulate their intrinsic excitability. Models with multiple sensors can distinguish among different patterns of activity, but previous work using models with multiple sensors produced instabilities that lead the models' conductances to oscillate and then to grow without bound and diverge. We now introduce a nonlinear degradation term that explicitly prevents the maximal conductances to grow beyond a bound. We combine the sensors' signals into a master feedback signal that can be used to modulate the timescale of conductance evolution.

SUBMITTER: Alonso LM 

PROVIDER: S-EPMC10293857 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature