Association of Age With Treatment-Related Adverse Events and Survival in Patients With Metastatic Colorectal Cancer.

ABSTRACT:

Importance

While the incidence of early-onset metastatic colorectal cancer (mCRC) has been increasing, studies on the age-related disparity in this group of patients are limited.

Objective

To evaluate the association of age with treatment-related adverse events and survival in patients with mCRC and explore the potential underlying factors.

Design, setting, and participants

This cohort study included 1959 individuals. Individual data on 1223 patients with mCRC who received first-line fluorouracil and oxaliplatin therapy in 3 clinical trials, and clinical and genomic data of 736 patients with mCRC from Moffitt Cancer Center were used to assess genomic alterations and serve as an external validation cohort. All statistical analyses were conducted from October 1, 2021, t

SUBMITTER: Meng L 

PROVIDER: S-EPMC10293914 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature