Heterogenous profiles between primary lung cancers and paired brain metastases reveal tumor evolution.

ABSTRACT:

Background

Brain metastases (BMs) are the most common central nervous system (CNS) malignant tumors, with rapid disease progression and extremely poor prognosis. The heterogeneity between primary lung cancers and BMs leads to the divergent efficacy of the adjuvant therapy response to primary tumors and BMs. However, the extent of heterogeneity between primary lung cancers and BMs, and the evolutionary process remains little known.

Methods

To deeply insight into the extent of inter-tumor heterogeneity at a single-patient level and the process of these evolutions, we retrospectively analyzed a total of 26 tumor samples from 10 patients with matched primary lung cancers and BMs. One patient underwent four times brain metastatic lesion surgery with diverse locations and one oper

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10293929 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature