Establishment of a prognostic model related to tregs and natural killer cells infiltration in bladder cancer.

ABSTRACT:

Background

Regulatory T cells (Tregs) and natural killer (NK) cells play an essential role in the development of bladder urothelial carcinoma (BUC).

Aim

To construct a prognosis-related model to judge the prognosis of patients with bladder cancer, meanwhile, predict the sensitivity of patients to chemotherapy and immunotherapy.

Methods

Bladder cancer information data was obtained from The Cancer Genome Atlas and GSE32894. The CIBERSORT was used to calculate the immune score of each sample. Weighted gene co-expression network analysis was used to find genes that will have the same or similar expression patterns. Subsequently, multivariate cox regression and lasso regression was used to further screen prognosis-related genes. The prrophetic package was used to predict p

SUBMITTER: Yang YJ 

PROVIDER: S-EPMC10294199 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature