Intramolecular Hydrogen-Bond Interactions Tune Reactivity in Biomimetic Bis(μ-hydroxo)dicobalt Complexes.

ABSTRACT: Active site hydrogen-bond (H-bond) networks represent a key component by which metalloenzymes control the formation and deployment of high-valent transition metal-oxo intermediates. We report a series of dinuclear cobalt complexes that serve as structural models for the nonheme diiron enzyme family and feature a Co₂(μ-OH)₂ diamond core stabilized by intramolecular H-bond interactions. We define the conditions required for the kinetically controlled synthesis of these complexes: [Co₂(μ-OH)₂(μ-OAc)(κ¹-OAc)₂(py^R)₄][PF₆] (1^R), where OAc = acetate and py^R = pyridine with para-substituent R, and we describe a homologous series of 1^R

SUBMITTER: DeLucia AA 

PROVIDER: S-EPMC10294290 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature