Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development.

ABSTRACT:

Background

The mammalian retina contains an autonomous circadian clock that controls various aspects of retinal physiology and function, including dopamine (DA) release by amacrine cells. This neurotransmitter plays a critical role in retina development, visual signalling, and phase resetting of the retinal clock in adulthood. Interestingly, bidirectional regulation between dopaminergic cells and melanopsin-expressing retinal ganglion cells has been demonstrated in the adult and during development. Additionally, the adult melanopsin knockout mouse (Opn4 ^-/-) exhibits a shortening of the endogenous period of the retinal clock. However, whether DA and / or melanopsin influence the retinal clock mechanism during its maturation is still unknown.

Results

Using wild-typ

SUBMITTER: Kinane C 

PROVIDER: S-EPMC10294308 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature