Huangqi decoction ameliorates kidney injury in db/db mice by regulating the BMP/Smad signaling pathway.

ABSTRACT:

Purpose

This study aims to investigate the mechanism underlying the beneficial effects of Huangqi decoction (HQD) on Diabetic kidney disease (DKD) in diabetic db/db mice.

Methods

Eight-week-old male diabetic db/db mice were randomly divided into four groups: Model (1% CMC), HQD-L (0.12 g/kg), HQD-M (0.36 g/kg), and HQD-H (1.08 g/kg) groups. Non-diabetic db/m mice were served as the control group. These mice received HQD treatment for 8 weeks. After treatment, the kidney function, histopathology, micro-assay, and protein expression levels were assessed.

Results

HQD treatment improved the albumin/creatine ratio (ACR) and 24 h urinary albumin excretion, prevented the pathological phenotypes of increased glomerular volume, widened mesangial areas, the of mesangial matrix

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10294356 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature