Post-prandial analysis of fluctuations in the platelet count and platelet function in patients with the familial chylomicronemia syndrome.

ABSTRACT:

Background

The familial chylomicronemia syndrome (FCS) is an ultra rare disease caused by lipoprotein lipase (LPL) deficiency associated with potentially lethal acute pancreatitis risk. Thrombocytopenia (platelet count < 150,000 × 10⁹/L) has been reported in patients with FCS, treated or not with volanesorsen, a second generation APOC3 anti-sense oligonucleotide. Chylomicrons are the lipoproteins delivering fat after a meal and FCS thus has a post-prandial origin. Platelet count and function have not been studied post-prandially in FCS.

Objective

To evaluate post-prandial fluctuations in the platelet count (PLC) and functional defects of hemostasis in FCS.

Methods

PLC, functional defects in hemostasis and hematologic variables were measured up-to 5 h after

SUBMITTER: Larouche M 

PROVIDER: S-EPMC10294360 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature