Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity.

ABSTRACT:

Background

Epigenetic processes are proposed to be a mechanism regulating gene expression during phenotypic plasticity. However, environmentally induced changes in DNA methylation exhibit little-to-no association with differential gene expression in metazoans at a transcriptome-wide level. It remains unexplored whether associations between environmentally induced differential methylation and expression are contingent upon other epigenomic processes such as chromatin accessibility. We quantified methylation and gene expression in larvae of the purple sea urchin Strongylocentrotus purpuratus exposed to different ecologically relevant conditions during gametogenesis (maternal conditioning) and modeled changes in gene expression and splicing resulting from maternal conditioning as func

SUBMITTER: Bogan SN 

PROVIDER: S-EPMC10294446 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature