Notch mediates the glycolytic switch via PI3K/Akt signaling to support embryonic development.

ABSTRACT:

Background

Energy metabolism disorder or insufficient energy supply during incubation will affect the development and survival of avian embryos. Especially, β-oxidation could not provide the continuous necessary energy for avian embryonic development due to the increasing energy demand under hypoxic conditions during the mid-late embryonic stages. The role and mechanism of hypoxic glycolysis replacing β-oxidation as the main source of energy supply for avian embryonic development in the mid-late stages is unclear.

Results

Here, we found that in ovo injection with glycolysis inhibitor or γ-secretase inhibitor both decreased the hepatic glycolysis level and impaired goose embryonic development. Intriguingly, the blockade of Notch signaling is also accompanied by the inhibition

SUBMITTER: Wang H 

PROVIDER: S-EPMC10294521 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature