The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies.

ABSTRACT:

Background

Withholding parenteral nutrition (PN) until one week after PICU admission facilitated recovery from critical illness and protected against emotional and behavioral problems 4 years later. However, the intervention increased the risk of hypoglycemia, which may have counteracted part of the benefit. Previously, hypoglycemia occurring under tight glucose control in critically ill children receiving early PN did not associate with long-term harm. We investigated whether hypoglycemia in PICU differentially associates with outcome in the context of withholding early PN, and whether any potential association with outcome may depend on the applied glucose control protocol.

Methods

In this secondary analysis of the multicenter PEPaNIC RCT, we studied whether hypoglycemia i

SUBMITTER: Gunst J 

PROVIDER: S-EPMC10294527 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature