Differentially expressed chaperone genes reveal a stress response required for unidirectional regeneration in the basal chordate Ciona.

ABSTRACT:

Background

Unidirectional regeneration in the basal chordate Ciona intestinalis involves the proliferation of adult stem cells residing in the branchial sac vasculature and the migration of progenitor cells to the site of distal injury. However, after the Ciona body is bisected, regeneration occurs in the proximal but not in the distal fragments, even if the latter include a part of the branchial sac with stem cells. A transcriptome was sequenced and assembled from the isolated branchial sacs of regenerating animals, and the information was used to provide insights into the absence of regeneration in distal body fragments.

Results

We identified 1149 differentially expressed genes, which were separated into two major modules by weighted gene correlation network analysis, one

SUBMITTER: Jeffery WR 

PROVIDER: S-EPMC10294541 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature