Light and heavy chain deposition disease with focal amyloid deposition diagnosed with mass spectrometry: a case report.

ABSTRACT:

Background

Light and heavy chain deposition disease (LHCDD) is a rare condition characterised by the deposition of immunoglobulin components in the kidneys. Similarly, Amyloidosis is also caused by the deposition of light chain and/or heavy chain components of immunoglobulins which are folded into amyloid fibrils characterised by Congophilic deposits that exhibit apple-green birefringence under polarised light. Only a handful of reports describing LHCDD with amyloid fibril deposition have been previously published, however, none have characterized the composition of the deposited immunoglobulin components via mass spectrometry.

Case presentation

We report a case of a 79-year-old Japanese woman with nephrotic syndrome. Bone marrow aspiration revealed a slight proliferation of

SUBMITTER: Shimamoto Y 

PROVIDER: S-EPMC10294544 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature