Mendelian randomization study reveals a causal relationship between serum iron status and coronary heart disease and related cardiovascular diseases.

ABSTRACT:

Background

Growing observational studies have shown that abnormal systemic iron status is associated with Coronary heart disease (CHD). However, these results from observational studies was not entirely consistent.It remains unclear whether this relationship represents causality.It is necessary to explore the causal relationship between iron status and CHD and related cardiovascular diseases (CVD).

Objective

We aimed to investigate the potential casual relationship between serum iron status and CHD and related CVD using a two-sample Mendelian randomization (MR) approach.

Methods

Genetic statistics for single nucleotide polymorphisms (SNPs) between four iron status parameters were identified in a large-scale genome-wide association study (GWAS) conducted by the Iron St

SUBMITTER: Liu F 

PROVIDER: S-EPMC10294586 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature