The ComRS-SigX Pathway Regulates Natural Transformation in Streptococcus ferus.

ABSTRACT: The ability to take up and incorporate foreign DNA via natural transformation is a well-known characteristic of some species of Streptococcus, and is a mechanism that rapidly allows for the acquisition of antibacterial resistance. Here, we describe that the understudied species Streptococcus ferus is also capable of natural transformation and uses a system analogous to that identified in Streptococcus mutans. S. mutans natural transformation is under the control of the alternative sigma factor sigX (also known as comX), whose expression is induced by two types of peptide signals: CSP (competence stimulating peptide, encoded by comC) and XIP (sigX-inducing peptide, encoded by comS). These systems induce competence

SUBMITTER: Rued BE 

PROVIDER: S-EPMC10294618 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature