LaeA-Regulated Fungal Traits Mediate Bacterial Community Assembly.

ABSTRACT: Potent antimicrobial metabolites are produced by filamentous fungi in pure culture, but their ecological functions in nature are often unknown. Using an antibacterial Penicillium isolate and a cheese rind microbial community, we demonstrate that a fungal specialized metabolite can regulate the diversity of bacterial communities. Inactivation of the global regulator, LaeA, resulted in the loss of antibacterial activity in the Penicillium isolate. Cheese rind bacterial communities assembled with the laeA deletion strain had significantly higher bacterial abundances than the wild-type strain. RNA-sequencing and metabolite profiling demonstrated a striking reduction in the expression and production of the natural product pseurotin in the laeA deletion strain. Inacti

SUBMITTER: Tannous J 

PROVIDER: S-EPMC10294623 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature