Genetic factors for differentiated thyroid cancer in French Polynesia: new candidate loci.

ABSTRACT:

Background

Populations of French Polynesia (FP), where France performed atmospheric tests between 1966 and 1974, experience a high incidence of differentiated thyroid cancer (DTC). However, up to now, no sufficiently large study of DTC genetic factors in this population has been performed to reach definitive conclusion. This research aimed to analyze the genetic factors of DTC risk among the native FP populations.

Methods

We analyzed more than 300 000 single nucleotide polymorphisms (SNPs) genotyped in 283 DTC cases and 418 matched controls born in FP, most being younger than 15 years old at the time of the first nuclear tests. We analyzed the genetic profile of our cohort to identify population subgroups. We then completed a genome-wide analysis study on the whole populatio

SUBMITTER: Zidane M 

PROVIDER: S-EPMC10294640 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature