Cryo-EM Structures of the Klebsiella pneumoniae AcrB Multidrug Efflux Pump.

ABSTRACT: The continued challenges of the COVID-19 pandemic combined with the growing problem of antimicrobial-resistant bacterial infections has severely impacted global health. Specifically, the Gram-negative pathogen Klebsiella pneumoniae is one of the most prevalent causes of secondary bacterial infection in COVID-19 patients, with approximately an 83% mortality rate observed among COVID-19 patients with these bacterial coinfections. K. pneumoniae belongs to the ESKAPE group of pathogens, a group that commonly gives rise to severe infections that are often life-threatening. Recently, K. pneumoniae carbapenemase (KPC)-producing K. pneumoniae has drawn wide public attention, as the mortality rate for this infection can be as high as 71%. The most predominant and clinically important multidrug effl

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10294659 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature