Dietary sugars silence the master regulator of carbohydrate utilization in human gut Bacteroides species.

ABSTRACT: The mammalian gut microbiota is a critical human health determinant with therapeutic potential for remediation of many diseases. The host diet is a key factor governing the gut microbiota composition by altering nutrient availability and supporting the expansion of distinct microbial populations. Diets rich in simple sugars modify the abundance of microbial subsets, enriching for microbiotas that elicit pathogenic outcomes. We previously demonstrated that diets rich in fructose and glucose can reduce the fitness and abundance of a human gut symbiont, Bacteroides thetaiotaomicron, by silencing the production of a critical intestinal colonization protein, called Roc, via its mRNA leader through an unknown mechanism. We have now determined that dietary sugars silence Roc by reducing th

SUBMITTER: Pearce VH 

PROVIDER: S-EPMC10294740 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature