A systematic review of the efficacy of ketamine for craniofacial pain.

ABSTRACT:

Background

Craniofacial pain (CFP) poses a burden on patients and health care systems. It is hypothesized that ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, can reverse central sensitization associated with causation and propagation of CFP. This systematic review aims to assess the role of ketamine for CFP.

Methods

Databases were searched for studies published up to September 26, 2022, investigating the efficacy of ketamine for adults with CFP. Primary outcome was the change in pain intensity at 60 min postintervention. Two reviewers screened and extracted data. Registration with PROSPERO was performed (CRD42020178649).

Results

Twenty papers (six randomized controlled trials [RCTs], 14 observational studies) including 670 patients were identifie

SUBMITTER: Hoydonckx Y 

PROVIDER: S-EPMC10294769 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature