Hyperpolarized Xenon-129: A New Tool to Assess Pulmonary Physiology in Patients with Pulmonary Fibrosis.

ABSTRACT:

Purpose

The existing tools to quantify lung function in interstitial lung diseases have significant limitations. Lung MRI imaging using inhaled hyperpolarized xenon-129 gas (¹²⁹Xe) as a contrast agent is a new technology for measuring regional lung physiology. We sought to assess the utility of the ¹²⁹Xe MRI in detecting impaired lung physiology in usual interstitial pneumonia (UIP).

Materials and methods

After institutional review board approval and informed consent and in compliance with HIPAA regulations, we performed chest CT, pulmonary function tests (PFTs), and ¹²⁹Xe MRI in 10 UIP subjects and 10 healthy controls.

Results

The ¹²⁹Xe MRI detected highly heterogeneous abnormalities within individual UIP subjects as compar

SUBMITTER: Qing K 

PROVIDER: S-EPMC10294784 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature