IntiCom-DB: A Manually Curated Database of Inter-Tissue Communication Molecules and Their Communication Routes.

ABSTRACT: Inter-tissue communication (ITC) is critical for maintaining the physiological functions of multiple tissues and is closely related to the onset and development of various complex diseases. Nevertheless, there is no well-organized data resource for known ITC molecules with explicit ITC routes from source tissues to target tissues. To address this issue, in this work, we manually reviewed nearly 190,000 publications and identified 1408 experimentally supported ITC entries in which the ITC molecules, their communication routes, and their functional annotations were included. To facilitate our work, these curated ITC entries were incorporated into a user-friendly database named IntiCom-DB. This database also enables visualization of the expression abundances of ITC proteins and their interact

SUBMITTER: Xiong C 

PROVIDER: S-EPMC10294874 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature