Systemic Inflammation, Endothelial Function, and Risk of Periodontitis in Overweight/Obese Adults.

ABSTRACT: The network interaction between systemic inflammatory mediators, endothelial cell adhesion function, and adiponectin as mediators of the association between metabolic diseases and periodontitis has not been evaluated. The objective of this study is to assess whether the interaction of baseline serum levels of TNF-α, hs-CRP, ICAM-1, VCAM-1, and adiponectin leads to periodontitis. Five hundred and ninety-seven overweight/obese (overweight: BMI 25 to <30 kg/m²; obese: >30 kg/m²) adults, aged 40-65 years, with complete 3-year follow-up data were included. Generalized structural equation models with negative binomial regression were used to estimate the regression coefficient (β) for the outcome number of teeth with probing pocket depth (PPD) ≥ 4 mm and bleeding on probing

SUBMITTER: Andriankaja OM 

PROVIDER: S-EPMC10294979 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature