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Ubiquinol Short-Term Supplementation Prior to Strenuous Exercise Improves Physical Performance and Diminishes Muscle Damage.

ABSTRACT: The benefits of physical exercise on health are diminished when it is non-planned, strenuous, or vigorous, which causes an increase in oxygen consumption and production of free radicals, particularly serious at the muscular level. Ubiquinol could help achieve an antioxidant, anti-inflammatory, and ergogenic effect. The aim of this study is to evaluate whether a supplementation of ubiquinol during a short period could have a positive effect on muscle aggression, physical performance, and fatigue perception in non-elite athletes after high intensity circuit weight training. One hundred healthy and well-trained men, (firemen of the Fire Department of Granada) were enrolled in a placebo-controlled, double-blinded, and randomized study, and separated into two groups: the placebo group (PG, n = 50); and the ubiquinol group (UG, n = 50), supplemented with an oral dose. Before and after the intervention, data related to the number of repetitions, muscle strength, and perceived exertion, as well as blood samples were collected. An increase was observed in the UG regarding average load and repetitions, revealing an improvement in muscle performance. Ubiquinol supplementation also reduced muscle damage markers, showing a protective effect on muscle fibers. Therefore, this study provides evidence that ubiquinol supplementation improves muscle performance and prevents muscle damage after strenuous exercise in a population of well-trained individuals who are not elite athletes.

SUBMITTER: Moreno-Fernandez J

PROVIDER: S-EPMC10295177 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Ubiquinol Short-Term Supplementation Prior to Strenuous Exercise Improves Physical Performance and Diminishes Muscle Damage.

Moreno-Fernandez Jorge J Puche-Juarez Maria M Toledano Juan M JM Chirosa Ignacio I Chirosa Luis J LJ Pulido-Moran Mario M Kajarabille Naroa N Guisado Isabel M IM Guisado Rafael R Diaz-Castro Javier J Ochoa Julio J JJ

Antioxidants (Basel, Switzerland) 20230531 6

The benefits of physical exercise on health are diminished when it is non-planned, strenuous, or vigorous, which causes an increase in oxygen consumption and production of free radicals, particularly serious at the muscular level. Ubiquinol could help achieve an antioxidant, anti-inflammatory, and ergogenic effect. The aim of this study is to evaluate whether a supplementation of ubiquinol during a short period could have a positive effect on muscle aggression, physical performance, and fatigue ...[more]

PMID: 37371923

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Project description:IntroductionEsports have been suggested to enhance hand-eye coordination, fine motor skills, and reaction times. While physical exercise is known to improve these abilities, its impact on short-term esports performance is under-researched. This study aims to evaluate the effects of specific and general physical training on gaming performance, hypothesizing improvements in both physical and gaming-related variables.MethodsBaseline and follow-up tests measured global coordination, grip strength, Aimlabs performance, single and 4-fold reaction times, and anticipation. Participants completed a weekly and an ending questionnaire. Twenty-eight participants (12.3 ± 10.1 h gaming/week) were assigned to specific (N = 10), general (N = 9), and no training (N = 9) groups for an 8-week intervention. Variable changes over time and between groups were analyzed using a repeated measures ANCOVA.ResultsTraining significantly improved the overall coordination of those participants engaging in physical training compared to the control group [F(2,25) = 3.858, p = 0.035, η 2 = 0.236]. Grip strength also showed significant improvement [F(2,25) = 6.084, p = 0.007, η 2 = 0.327]. There were no significant time or group effects for the gaming variables, but the hours played by participants positively influenced Grid Shot [F(1,24) = 4.746, p = 0.039, η 2 = 0.165] and Track Point [F(1,24) = 9.613, p = 0.005, η 2 = 0.286] performance. The weekly questionnaire indicated a significant improvement in participants' well-being.DiscussionWhile training improved physical variables, no effects were observed in suggested short-term performance. However, gaming hours and experience during the intervention positively influenced performance. Future research should consider the amount of time spent playing as it may affect short-term performance. Furthermore, future research should strive to differentiate between various types of esports performance, such as short-term vs. long-term outcomes. Participants reported that engaging in physical activity within the context of esports and gaming positively contributed to their overall well-being.Clinical trial registrationClinicalTrials.gov, identifier (NCT06264375).

Project description:Probiotics exert multiple health benefits, including gastrointestinal health, immunoregulation, and metabolic disease improvement, by modulating microbiota to maintain eubiosis via the hypothalamic-pituitary-adrenal (HPA) and brain-gut-microbiome axes. Physiological fatigue, mental stress, and gastrointestinal discomfort under the demands of athletic performance as well as immunosuppression are common during endurance training and competition. Limited studies investigated the functional effects of probiotic supplementation on endurance training. Bifidobacterium longum subsp. Longum OLP-01 (OLP-01), isolated from an elite Olympic athlete, was combined with a six-week exercise training program with gradually increasing intensity. In this study, Institute of Cancer Research (ICR) mice were assigned to sedentary, exercise, OLP-01, or exercise + OLP-01 groups and administered probiotic and/or treadmill exercise training for six weeks to assess exercise performance, physiological adaption, and related metabolites. The exercise + OLP-01 group demonstrated higher performance in terms of endurance and grip strength, as well as improved fatigue-associated indexes (lactate, ammonia, creatine kinase (CK), lactate dehydrogenase (LDH), and glycogen content), compared with the other groups. OLP-01 supplementation significantly ameliorated inflammation and injury indexes (platelet/lymphocyte ratio (PLR), aminotransferase (AST), and CK) caused by prolonged endurance exercise test. Moreover, acetate, propionate, and butyrate levels were significantly higher in the exercise + OLP-01 group than in the sedentary and OLP-01 groups. Athletes often experience psychological and physiological stress caused by programed intensive exercise, competition, and off-site training, often leading to poor exercise performance and gastrointestinal issues. Functional OLP-01 probiotics are considered to be a nutritional strategy for improving physiological adaption, oxidative stress, inflammation, and energy balance to ensure high physical performance. Based on these results, probiotics combined with exercise training is a potential strategy for ensuring high physical performance of athletes, which should be further investigated through microbiota validation.

Project description:The purpose of this study was to investigate the impact of antioxidant-rich marine phytoplankton supplementation (Oceanix, OCX) on performance and muscle damage following a cross-training event in endurance-trained subjects. Additionally, an animal model was carried out to assess the effects of varying dosages of OCX, with exercise, on intramuscular antioxidant capacity. METHODS:In the human trial, endurance-trained subjects (average running distance = 29.5 ± 2.6 miles × week-1) were randomly divided into placebo (PLA) and OCX (25 mg) conditions for 14 days. The subjects were pre-tested on a one-mile uphill run, maximal isometric strength, countermovement jump (CMJ) and squat jump (SJ) power, and for muscle damage (creatine kinase (CK)). On Day 12, the subjects underwent a strenuous cross-training event. Measures were reassessed on Day 13 and 14 (24 h and 48 h Post event). In the animal model, Wistar rats were divided into four groups (n = 7): (i) Control (no exercise and placebo (CON)), (ii) Exercise (E), (iii) Exercise + OCX 1 (Oceanix, 2.55 mg/day, (iv) Exercise + OCX 2 (5.1 mg/day). The rats performed treadmill exercise five days a week for 6 weeks. Intramuscular antioxidant capacity (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px)) and muscle damage (CK and myoglobin (MYOB) were collected. The data were analyzed using repeated measures ANOVA and t-test for select variables. The alpha value was set at p < 0.05. RESULTS:For the human trial, SJ power lowered in PLA relative to OCX at 24 h Post (-15%, p < 0.05). Decrements in isometric strength from Pre to 48 h Post were greater in the PLA group (-12%, p < 0.05) than in the OCX. Serum CK levels were greater in the PLA compared to the OCX (+14%, p < 0.05). For the animal trial, the intramuscular antioxidant capacity was increased in a general dose-dependent manner (E + Oc2 > E + Oc1 > E > CON). Additionally, CK and MYOB were lower in supplemented compared to E alone. CONCLUSIONS:Phytoplankton supplementation (Oceanix) sustains performance and lowers muscle damage across repeated exercise bouts. The ingredient appears to operate through an elevating oxidative capacity in skeletal muscle.

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Ubiquinol Short-Term Supplementation Prior to Strenuous Exercise Improves Physical Performance and Diminishes Muscle Damage.

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Ubiquinol Short-Term Supplementation Prior to Strenuous Exercise Improves Physical Performance and Diminishes Muscle Damage.

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