MiR-34a-5p as molecular hub of pathomechanisms in Huntington's disease.

ABSTRACT:

Background

Although a pivotal role of microRNA (miRNA, miR) in the pathogenesis of Huntington's disease (HD) is increasingly recognized, the molecular functions of miRNAs in the pathomechanisms of HD await further elucidation. One of the miRNAs that have been associated with HD is miR-34a-5p, which was deregulated in the mouse R6/2 model and in human HD brain tissues.

Methods

The aim of our study was to demonstrate interactions between miR-34a-5p and HD associated genes. By computational means we predicted 12 801 potential target genes of miR-34a-5p. An in-silico pathway analysis revealed 22 potential miR-34a-5p target genes in the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway "Huntington's disease".

Results

Using our high-throughput miRNA interaction reporte

SUBMITTER: Hart M 

PROVIDER: S-EPMC10295337 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature