Evolutionary Stability of Small Molecular Regulatory Networks That Exhibit Near-Perfect Adaptation.

ABSTRACT: Large-scale protein regulatory networks, such as signal transduction systems, contain small-scale modules ('motifs') that carry out specific dynamical functions. Systematic characterization of the properties of small network motifs is therefore of great interest to molecular systems biologists. We simulate a generic model of three-node motifs in search of near-perfect adaptation, the property that a system responds transiently to a change in an environmental signal and then returns near-perfectly to its pre-signal state (even in the continued presence of the signal). Using an evolutionary algorithm, we search the parameter space of these generic motifs for network topologies that score well on a pre-defined measure of near-perfect adaptation. We find many high-scoring parameter sets across

SUBMITTER: Singhania R 

PROVIDER: S-EPMC10295370 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature